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KMID : 0043320100330122033
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Archives of Pharmacal Research
2010 Volume.33 No. 12 p.2033 ~ p.2036
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Crystal forms of SK-3530
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Song Hyun-Ok
Sohn Young-Taek
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Abstract
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The objective of this work was to investigate the existence of polymorphs of SK-3530 and the transformation of crystal forms. Two crystal forms of SK-3530 have been isolated by recrystallization and characterized by differential scanning calorimetry, powder X-ray diffractometry and thermogravimetric analysis. The differential scanning calorimetry and powder X-ray diffractometry patterns of two crystal forms were different respectively. After storage of 1 month at 0% RH (silica gel, 20°C), 52% RH (saturated solution of Na2Cr2O7·2H2O/20°C) and 95% RH (saturated solution of Na2HPO4/20°C), Form 2 was not transformed to Form 1 and two forms were shown to have a good physical stability at room temperature for 1 month. In the dissolution studies in pH 6.8 buffer at 37 ± 0.5°C, the dissolution rate of Form 2 was significantly higher than that of Form 1 under 30 min.
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KEYWORD
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Crystal form, SK-3530, Polymorphism, Differential scanning calorimetry, Powder X-ray diffractometry, Thermogravimetric analysis, Transformation
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